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Pregnyl (Hcg) 1 Ampoule 5000iu

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Pregnyl (Hcg) 1 Ampoule 5000iu contains the active substance human chorionic gonadotrophin (HCG). Every ampoule contains 5,000 international units of hCG. The action of Pregnyl is similar to that of the natural luteinising hormone (LH), which is necessary for the production of sex hormones, the growth and development of egg cells in the females and for the production of sperm in the males. This is a prescription only product.

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Pregnyl (Hcg) 1 Ampoule 5000iu:

How does it work?

Pregnyl injections contain the active ingredient chorionic gonadotrophin, which is a natural sex hormone also known as human chorionic gonadotropin or HCG.


For Women

In women, HCG is used together with other hormones called follicle stimulating hormone (FSH) and luteinising hormone (LH) in the treatment of infertility.


Pregnyl injections are used to stimulate follicules to mature and ovulation to occur in women who are having difficulties getting pregnant due to problems with their natural ovulation, or who are having in-vitro fertilisation (IVF) treatment.


For Men

HCG also mimics the action of luteinising hormone in men. The effect of this in men is to stimulate production of the male hormone, testosterone.


This medicine is used in the management of delayed puberty, undescended testicles and low sperm count in men, all of which are improved by increased testosterone levels. The injections are given two to three times a week for a few weeks, the length of treatment depending on the condition being treated.


Pregnyl injections are administered either under the skin (subcutaneously) or into a muscle (intramuscularly). If you are going to administer the injections yourself, your doctor will show you how to inject them under the skin.


What is it used for?

  • Stimulating the release of eggs (ovulation) in women having treatment for infertility caused by problems with their natural ovulation.
  • Stimulating the final maturation of eggs in women having in-vitro fertilisation (IVF) treatment.
  • Low sperm count (oligospermia) in men.
  • Delayed puberty in boys. This is when boys do not develop secondary sexual characteristics at the normal age (12 - 14 years old).
  • Testicles which have not dropped in boys.

Pregnyl (Hcg) 1 Ampoule 5000iu:

How should Pregnyl be used? When given under a muscle (intramuscular) the injection should be given by the doctor or nurse. When administered under the skin (subcutaneously) the injection may, in some cases, be given by you or your partner. Your doctor will tell you when and how to do this.

How much?

The dose is chosen by the doctor.

Women patients undergoing ovulation induction:

5,000-10,000 I.U. Pregnyl following treatment with gonadotrophins.

Up to 3 repeat injections of up to 5,000 I.U. each may be given within the following 9 days.

Women patients undergoing assisted pregnancy techniques:

5,000-10,000 I.U. Pregnyl 30-40 hours after the last gonadotrophins injection.


Hypogonadotrophic hypogonadism (absent sexual development):

500-1,000 I.U. 2-3 times weekly.

Delayed puberty:

1500 I.U. twice weekly for at least 6 months.

Sterility due to deficient production of sperm (spermatogenesis):

Usually, 3,000 I.U. per week in combination with a gonadotrophin.

Please inform your doctor or nurse if you think that you have missed a dose of Pregnyl or taken it at the wrong time.

How are the injections given?

The very first injection of Pregnyl should only be given under medical supervision. The dry powder should be dissolved with the solvent contained in the ampoule containing fluid and this solution should be administered immediately. The injections are given slowly into a muscle (for instance in the buttock, upper leg or upper arm) or just under the skin (in the abdominal wall, for example).

If you administer Pregnyl to yourself, follow the instructions on this leaflet carefully and Pregnyl will be administered properly and with minimal discomfort.

Pregnyl (Hcg) 1 Ampoule 5000iu: Before treatment with Pregnyl your doctor should have checked that your sexual organs are normal and that you do not have thyroid or adrenal problems. In women patients your doctor should have checked how your ovaries are working before starting treatment with Pregnyl.

Tell your doctor if you have, or have ever had:

  • heart problems
  • kidney problems
  • high blood pressure
  • epilepsy
  • migraine

This product should be used with caution in the treatment of boys who have not reached puberty. This is because it can cause early sexual development and may result in final adult height not being reached.

If you have risks factors for having a blood clot (for example being overweight, or if blood clots run in your family), the chance of having a blood clot may be increased during IVF treatment. Remember though that being pregnant increases the chance of having a blood clot.

Pregnancy: If treatment with Pregnyl results in pregnancy, there is an increased chance of having twins or multiplets. There is also an increased chance of a miscarriage, or a pregnancy outside of the womb- an ectopic pregnancy.

What other medicines are you taking? Other medicines may affect how Pregnyl works or Pregnyl may affect how they work. Tell your doctor if you are using/taking (or intend to use/take) any other medicines.

Pregnyl (Hcg) 1 Ampoule 5000iu:

Pregnyl sometimes causes side-effects in some people. The following side-effects have been reported:

  • Rash
  • fluid retention
  • headache
  • tiredness
  • mood changes
  • painful breasts
  • acne

In rare cases blood clots or fever may occur.

If you suffer from any side-effects especially pain in your abdomen you should consult your doctor, he may decide to stop the treatment for a while.

Pregnyl (Hcg) 1 Ampoule 5000iu:The active substance in Pregnyl is human chorionic gonadotrophin (HCG). Every ampoule contains 5,000 international units (I.U.) of hCG.

Pregnyl also contains:

  • sodium carboxymethylcellulose
  • mannitol
  • disodium hydrogen phosphate (anhydrous)
  • sodium dihydrogen phosphate (anhydrous)

The solvent contains sodium chloride (9 mg) and water for injections.

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