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Prascend 1mg Tablet (Pergolide 1mg)

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Prascend 1mg Tablet (Pergolide 1mg is a private prescription item. To purchase this item you must have a private prescription. Prascend is the first licensed medicine for the treatment of clinical signs associated with PPID in horses (Equine Cushings Disease).

Prascend 1mg Tablet (Pergolide 1mg): Prascend is the first licensed medicine for the treatment of clinical signs associated with PPID in horses (Equine Cushing's Disease). Prascend is normally given once daily, and can be mixed with a small volume of molasses or food to ease administration, or alternatively by dissolving in a small volume of water and administering directly into the mouth. As Prascend affects cortisol production, there is usually a short lag between beginning treatment (reducing cortisol production) and seeing your horse return to normal in terms of clinical signs (as levels of cortisol in the body become normal again). It can take up to 6-12 weeks to see the full benefit of treatment.

Indicators of PPID include:

  • Excessive sweating
  • Increased appetite
  • Increased drinking and urination
  • Lethargy / poor performance
  • Repeating episodes of laminitis
  • Recurring infections (eg: sinusitis)
  • Loss of muscle condition, and/or a pot bellied appearance

What is Cushing's Disease (PPID)?
Equine Cushing's Disease is the most common problem affecting the endocrine (hormonal) system of horses and ponies.

What causes the disease?
The hypothalamus and pituitary gland, which sit deep inside the skull at the base of the equine brain, are the command centre for the production of hormones. These chemical messengers are distributed around the horse's body via the bloodstream to all other tissues. In a normal horse, these exist in a fine balance, and play an important role in maintaining and controlling bodily functions.

In some older horses and ponies, neurones (nerves) in the hypothalamus undergo progressive degeneration, and produce insufficient quantities of a nerve transmitter substance (neurotransmitter) called dopamine. Dopamine is important in controlling the secretions of a part of the pituitary gland called the pars intermedia, which in turn is responsible for controlling the secretion of a hormone called cortisol in the adrenal glands.

When the pars intermedia is not exposed to enough dopamine from the hypothalamus, the ultimate outcome is the production of abnormally high levels of cortisol, which results in the symptoms associated with the disease. For this reason, Equine Cushings Disease is nowadays more correctly termed Equine Pituitary Pars Intermedia Dysfunction or PPID".


How to take:

Please take Prascend Tablet 1mg as prescribed by your medical professional  Direction details will be available on the medication container.

Please contact your medical practitioner to understand more about the side effects of taking Prascend Tablet 1mg.

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