Ovesse 1mg/g Vaginal Cream 15g Tube + Applicator 15g

Please note images are for illustration purposes and may differ from the product(s) you receive

Product details

Ovesse 1 mg/g vaginal cream is a local vaginal Hormone Replacement Therapy (HRT) designed to relieve symptoms of Genitourinary Syndrome of Menopause, such as vaginal dryness, irritation, itching, and painful intercourse. It contains estriol, a form of oestrogen that helps restore the natural balance of hormones in postmenopausal women aged 50 and above who haven�t had a period for at least one year. By delivering oestrogen directly to the vaginal area, Ovesse helps improve the condition of the vaginal wall, making it thicker, more elastic, and better hydrated, thereby easing discomfort and enhancing overall vaginal health.

What are the key features?

Active Ingredient: Estriol (1 mg/g)
Purpose: Local vaginal HRT for postmenopausal women
Target Symptoms: Vaginal dryness, soreness, or irritation. Itching or burning sensation. Painful sexual intercourse
Mechanism: Replaces oestrogen directly in the vaginal area
Indication: For women aged 50 with oestrogen deficiency and no periods for at least 1 year
Application: Vaginal insertion for targeted relief

Warnings / Side effects

DO NOT use Ovesse if you:

Are allergic to estriol or any of the other ingredients
Have or ever had womb or ovarian cancer
Have or recently had vaginal or genital bleeding, since your periods stopped due to the menopause
Have recent of suspected endometrial hyperplasia (or e.g. you have been referred for an ultrasound or your womb and are awaiting results)
Have previously been treated with oestrogen only systemic HRT (without Progestogen) and you have not had your womb removed
Have any thickening, lump or scarring on your vulva
Have severe vaginal itching, or itchy patches or rash on your vulva
Have a current vaginal infection prior to starting treatment
Have or ever had breast cancer, or have a lump / change in appearance in your breast, or nipple discharge
Have or ever had a blood clot in a vein
Have or ever had a heart attack, stroke or angina
Have blood clotting disorder
Have liver disease and your liver function tests have not returned to normal
Have a rare condition called 'porphyria'

Certain conditions may be made worse during oestrogen treatment, see section 2 of the package leaflet for more information.

You may need to speak to your doctor before using Ovesse. Ask your pharmacist for advice if you:

Are receiving a type of HRT (including tablets or patches) that circulates in the blood
Have a history of endometriosis
Have a history of excessive thickening of the womb lining
Are switching from another vaginal oestrogen

Stop using Ovesse and see a doctor immediately if you notice any of the following during treatment:

Any of the conditions mentioned in the 'DO NOT use Ovesse' section
Any new vaginal bleeding, spotting or itching
If you have endometriosis and your symptoms come back.

Seek prompt advice from your doctor if you:

Have yellowing of your skin or the whites of your eyes (jaundice)

You should inform your doctor at your next appointment that you are using Ovesse.

Keep all medicines out of the sight and reach of children

Usage / Instructions

Always use Ovesse exactly as described in this leaflet or as your pharmacist has told you. Check with your pharmacist if you are not sure.

This medicine is for vaginal use only. You will need to fill the applicator with cream from the tube yourself. Treatment with Ovesse vaginal cream may be started on any day.

How much to use

Initial dose: 1 applicator filled up to the red ring mark (0.5 mg estriol in 0.5 g of cream) a day for 2 weeks.
Maintenance dose: 1 applicator filled up to the red ring mark twice a week (3 or 4 days between each dose).
Restarting treatment after a break: You can restart using Ovesse at any time provided it is still suitable and your overall health is unchanged. If you are still experiencing symptom relief after a break from treatment with Ovesse, it is recommended that treatment is restarted at the maintenance dose. If you are experiencing bothersome symptoms again after a break from treatment with Ovesse, it is recommended to restart treatment at the initial daily dose regimen for 2 weeks, followed by the twice weekly maintenance dose.

Do NOT use more than the recommended dose

How to apply the cream: Ovesse comes in a pack together with a clear plastic applicator. Use the applicator to apply the cream in the vagina. A good time to do this is before going to bed. The applicator has a red ring marked on the body. Fill the applicator up to the red ring mark with Ovesse vaginal cream to get the correct dose.

Follow these instructions:

1. Remove the cap from the tube and turn the cap upside down. Then use the sharp point to open the tube.
2. Screw the end of the applicator onto the tube.
3. Squeeze the tube to fill the applicator with the cream up to the red ring mark (the plunger will stop at the red ring mark).
4. Unscrew the applicator from the tube and put the cap back on the tube. To apply the cream, lie down, put the end of the applicator deep into your vagina and slowly push the plunger all the way in.

Cleaning the applicator: After use, pull the plunger out of the barrel. Wash the plunger and barrel in hand hot, soapy water. Do not use detergents. Rinse well with clean water afterwards. Do not put the applicator in boiling water. Ovesse is easy to remove with water. Speak to your pharmacist if you experience any difficulties with using the vaginal applicator.

Ingredients

The active substance is estriol. Each gram of cream contains 1 milligram of estriol.

The other ingredients are chlorhexidine dihydrochloride, octyldodecanol, cetyl palmitate, glycerin, cetyl alcohol, stearyl alcohol, polysorbate 60, sorbitan stearate, lactic acid, sodium hydroxide and purified water.

Delivery & Returns

Royal Mail Tracked 48hr Delivery

£3.49 for Tracked 48hr service, delivered within 2-3 working days from despatch of order.
Free delivery for orders over £35
Delivered Mon-Sat (excluding Sunday and Bank Holidays).
Order by 8pm Monday to Friday for same day despatch.
All orders can be tracked from despatched to delivery, tracking code will be emailed to you.
Certain items cannot be delivered through this service and therefore this service not be visible in the checkout. Additional terms and conditions apply, please see the delivery page.

EVRI UK Tracked 48hr Service

£3.49 for Standard service, delivered within 2 working days from despatch of order.
Free standard delivery for orders over £35
Delivered Mon-Fri (excluding weekend and bank holidays).
Order by 8pm Sunday to Friday for same day despatch. Terms and conditions apply, see below.
Additional terms and conditions apply, please see below.

94% of orders are despatched within 2 days (data taken from July 2022 to October 2022)

Royal Mail Tracked 24hr Delivery

£5.09 for the Tracked 24hr service.
Mon-Thur orders placed before 8pm will be delivered 1-2 days from despatch (90% of orders delivered next day).
Friday orders placed before 8pm will be delivered from Saturday.
Weekend orders will be delivered from Tuesday.
Delivered Mon-Sat (excluding Sunday and Bank Holidays).
Order by 8pm Monday to Friday for same day despatch. Terms and conditions apply, see below
Pharmacy approved items will be despatched once approved and delivered the next working day.
All orders can be tracked from despatched to delivery, tracking code will be emailed to you.
Certain items cannot be delivered through this service and therefore this service not be visible in the checkout. Additional terms and conditions apply, please see below.

EVRI UK Tracked 24hr service

£5.09 for UK Next Working Day Delivery.
Sun-Fri orders placed before 8pm will be delivered the next day.
Friday orders placed after 8pm will be delivered on Monday.
Weekend orders will be delivered on Monday.
Delivered Mon-Fri (excluding bank holidays).
Order by 8pm Sunday to Friday for same day despatch. Terms and conditions apply, see below.
Pharmacy approved items will be despatched once approved and delivered the next day.
All orders can be tracked from despatched to delivery, tracking code will be emailed to you.
Additional terms and conditions apply, please see below.

EVRI Click & Collect tracked 48hr service

£3.00 for Standard service, delivered within 2 working days from despatch of order.
Free standard delivery for orders over £35
Delivered Mon-Fri (excluding weekend and bank holidays).
Order by 8pm Sunday to Friday for same day despatch. Terms and conditions apply, see below.
Additional terms and conditions apply, please see below.

EVRI UK Click & Collect tracked 24hr service

£3.49 for UK Next Working Day Delivery.
Sun-Fri orders placed before 8pm will be delivered the next day.
Friday orders placed after 8pm will be delivered on Monday.
Weekend orders will be delivered on Monday.
Delivered Mon-Fri (excluding bank holidays).
Order by 8pm Sunday to Friday for same day despatch. Terms and conditions apply, see below.
Pharmacy approved items will be despatched once approved and delivered the next day.
All orders can be tracked from despatched to delivery, tracking code will be emailed to you.
Additional terms and conditions apply, please see below.

UK Express Delivery

Free Express Delivery when you spend £100
Mon-Wed orders placed before 8pm will be delivered in 2 working days
Thursday orders placed before 8pm will be delivered on Monday
Friday orders placed before 8pm will be delivered on Tuesday
Weekend orders will be delivered on Tuesday
Delivered Mon-Fri (excluding bank holidays)
Order by 8pm Monday to Friday for same day despatch. Terms and conditions apply, see below.
Once approved P-line items will be delivered the next working day
Additional terms and conditions apply, please see below
Select Next working day delivery in the checkout for Express Delivery