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Menopur is used:
• To induce follicular maturation during the management of infertility caused by the failure of the ovaries to produce eggs (anovulatory infertility)
• In in vitro fertilisation (test tube) procedures or other assisted conception techniques to induce multiple follicular development.
Only a doctor can prescribe this medicine. It should never be given to anyone except the person it has been prescribed for. It may harm them even if they have the same symptoms. Please read this information carefully before starting treatment with the medicine. This leaflet does not contain the complete information, so if you have any questions or there is anything you are unsure about, ask your doctor or pharmacist.
• To treat poor sperm count (oligospermia).
BEFORE STARTING TREATMENT WITH YOUR MEDICINE
Do not use Menopur if:
• you have tumours of the pituitary gland or hypothalamus
• you are allergic to the active substance or any other
ingredients in Menopur
• you have high levels of a hormone called prolactin
Females should not use Menopur if:
• you have tumours of the uterus, ovaries or breasts
• you have cysts on the ovaries, or enlarged ovaries not
due to polycystic ovary syndrome (a condition
preventing eggs from being released from the ovaries)
• you are a pregnant or nursing mother
• you have unexplained bleeding from the vagina
• your ovaries are not functioning properly
• you have blocked fallopian tubes, unless undergoing IVF
(in vitro fertilisation) or ICSI (intracytoplasmic sperm
• you have premature menopause
• you have a physical defect of your reproductive organs
(uterus, tubes, ovaries and/or cervix)
• your uterus has been removed
• you have fibroid tumours (non cancerous tumours of the
Males should not use Menopur if:
• you have tumours of the testes
• you have prostate cancer
Before you begin treatment with Menopur, your doctor
will normally check the following:
• your thyroid and adrenal glands are working properly
• your ovaries are working properly
• you do not have tumours of the pituitary gland or
• you do not have higher than normal blood levels of a
hormone called prolactin, which can affect infertility.
Tell your doctor or nurse if you have or have had any of
• previous treatment for infertility
• a personal or family history of having blood clots.
Treatment with Menopur may increase the risk of having
a clot(s) and pregnancy itself increases the risk of having
USING YOUR MEDICINE
Depending on which condition you are being treated for, the
appropriate dose is administered by intramuscular injection
(into a muscle) or subcutaneous injection (just under the skin).
There are many different dosage schemes but common
In the female:
To induce follicular maturation:
In menstruating patients treatment should be started within
the first 7 days of the menstrual cycle. Menopur may be given
daily for up to 3 weeks to provide a dose of 75 to 150 units
until there is an adequate response. Alternatively, three equal
doses of Menopur, each providing 225 to 375 units may be
given on alternate days.
To induce multiple follicular development:
Stimulation of follicular growth is produced by Menopur in
daily doses of 75 to 300 units. Treatment is continued until an
adequate response is obtained.
Menopur is given in a dose of 75 or 150 units two or three
times weekly. Treatment is normally continued for at least 3 or
If you think you have missed a dose or you have been given
too much Menopur, please tell a nurse or doctor.
Once the Menopur dry powder has been mixed with the
solvent it should be used straight away.
Menopur is not recommended for children or elderly patients.
POSSIBLE SIDE EFFECTS
The use of Menopur may cause harmful over stimulation of
the ovaries. If you experience pain or swelling of the
abdomen, weight gain, difficulty breathing, increased thirst,
decreased urine output, nausea, vomiting and diarrhoea, tell
your doctor immediately.
Like all medicines this medicine can also have side effects.
Commonly reported side effects include over stimulation of
the ovaries, headache, nausea and vomiting, pain and/or
swelling of the abdomen, pain and/or inflammation at the
Uncommonly reported side effects include deep vein
thrombosis (clot formation in the veins, usually of the leg).
Very rarely, allergic reactions have been reported after
treatment with products containing gonadotrophins e.g.
In very rare cases, the long term use of menotrophin
containing products can lead to the formation of antibodies,
making treatment ineffective.
If you experience one or more of these side effects, or any
other undesirable effects, please inform your doctor or nurse.
If treatment with Menopur results in pregnancy:
• there is a possibility that pregnancy from treatment with
Menopur may result in multiple births (more than one
baby). This carries an increased risk of problems for the
mother during the pregnancy and at or around the time
• there is a risk of an ectopic pregnancy (where a fertilised
egg implants outside the uterus) if you have had a
history of tubal disease
• in patients undergoing infertility treatment, there is a
greater risk of miscarriage or abortion than in the general
population. There may be a slighty higher risk of your
baby being born with physical defects.
STORING YOUR MEDICINE
Menopur should be stored at a temperature not greater than
25°C. It must also be protected from light. Do NOT use
Menopur if it is past the expiry date on the packaging.
If you are unsure about the storage ask your pharmacist. It is
best to return all old and unused medication to your
pharmacist for safe disposal.
All medicines should be stored away from children.
ABOUT YOUR MEDICINE
Menopur is a sterile freeze dried powder for injection. It contains the active ingredient menotrophin BP 75 Units and the inactive carrier, lactose and sodium hydroxide and hydrochloric acid to adjust the pH. It is supplied in boxes of 5 or 10 vials of Menopur packaged together with 5 or 10 ampoules of Solvent 1 ml (Sodium Chloride Solution for Injections 0.9%w/v) used to dissolve the powder before it is injected. The solvent contains water for injection with sodium chloride to adjust the concentration and hydrochloric acid to adjust the acidity of the solution to values that are suitable for injection. Germany and the solvent is Weimer Pharma GmbH, Im
Menotrophin contains follicle stimulating hormone and luteinising hormone, two natural hormones produced in both males and females, and is obtained from the urine of post menopausal women. These hormones help to maintain the normal function of the reproductive organs in both males and females.
Menopur should only be used for the management of infertility under the supervision of a specialist.
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