1. What is Accupro?
The active ingredient, quinapril, belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors work by widening blood vessels in the body, which can reduce the pressure in the vessels.
2. What is Accupro used for?
Accupro is an ACE inhibitor used to treat high blood pressure and to help treat heart failure.
3. Before taking Accupro
Do not take Accupro
- If pregnant, planning to become pregnant or are breast feeding. Talk to your doctor to check adequate contraception, if you still have potential to have children.
- If you ever had a reaction to Accupro, any of its ingredients or similar drugs.
- If you have angio-oedema.
If the answer to any of the questions is \'yes\' you should speak to your doctor or pharmacist before you start taking Accupro as it may not be suitable for you.
- Do you suffer from allergies or asthma?
- Do you have diabetes?
- Do you have aortic stenosis (narrowing of the main blood vessel from the heart)?
- Do you have kidney or liver disease?
- Do you use a haemodialysis machine (an artificial kidney)?
- Are you taking any other blood pressure medications?
- Are you taking other medicines containing tetracycline, lithium, potassium supplements (this includes salt substitutes which often contain potassium) or other blood pressure tablets, steroids (for example hydrocortisone, dexamethasone or prednisolone), ACTH (tetracosactide) or non-steroidal anti-inflammatory pain killers (for example aspirin or ibuprofen), procainamide, cytostatic drugs, immunosuppressants, allopurinol, sympathomimetics, drugs to treat diabetes, indigestion/heartburn medicines (antacids) or sedatives?
- Are you taking diuretics (water tablets) as well as Accupro? If so then talk to your doctor before taking Accupro, if you have not already done so, as he may want to observe you when you take your first dose.
- Do you have collagen vascular disease (e.g. dermatomyositis, lupus erythematosus, polyarteritis nodosa)?
- Are you having, or about to have, low density lipoprotein apheresis treatment (removal of cholesterol from your blood by machine)?
- Are you having, or about to have, desensitisation treatment, i.e. to reduce the effects of an allergy to a bee or wasp sting?
- Are you drinking alcohol or taking sleeping pills?
If you go into hospital or visit a dentist, remember to tell them that you are taking Accupro. This is important if you go into hospital for an operation as your anaesthetist will want to know.
4. How to take Accupro
- Accupro is usually taken once or twice a day. You will start on a low dose which may be increased if necessary by your doctor until you are taking exactly the amount you need.
For hypertension (high blood pressure) the starting dose is usually 10 mg, which may be increased to 20 to 40 mg and up to a maximum of 80 mg a day.
For heart failure, or treatment with Accupro plus a diuretic, the starting dose is usually 2.5 mg, which may be increased up to 10 to 40 mg a day.
Occasionally, some people need higher doses than this. Whatever dose you have been prescribed, follow your doctor\'s instructions exactly and never change the dose yourself.
- Accupro should only be taken by mouth. Try to take the tablets at the same time/s every day, either with or without food.
- If you forget to take a dose, take it as soon as you remember unless it is time for your next dose. Do not take two doses at the same time.
- If you accidentally take too much Accupro, tell your doctor at once. If you can\'t do this, go to the nearest hospital accident and emergency department. Take along any tablets that are left, the container and the label so that the hospital staff can easily tell what medicine you have taken.
- Accupro should not be used in children under 12 years of age.
Like all other medicines, as well as helping your illness, Accupro can sometimes cause unwanted effects (side-effects).
The following effects are very rare but are serious and so you should tell your doctor at once if they occur.
- Angio-oedema (swelling of the face, tongue and windpipe which can cause great difficulty in breathing). At the same time or independently, angioedema can affect your stomach and bowels (intestinal angioedema - swelling of the gut lining) in which case you will feel unwell, may have to vomit and experience abdominal pain. These are very rare reactions, but they can be very serious if they occur. You should call an ambulance at once if they happen.
- If you have a tight chest, chest pain, palpitations, wheezing or trouble breathing.
- If you develop a severe sore throat or severe mouth ulcers, particularly if you have kidney problems or collagen vascular disease, you may not have enough white blood cells (Neutropenia/agranulocytosis - a lack of certain white blood cells) which may lead to infection, sore throat or fever. If you have a collagen vascular disease your doctor may perform routine tests to check your blood.
- Feeling faint particularly when standing may mean your blood pressure is too low. This is more likely to occur if you have been taking diuretics (water tablets), other blood pressure medications in addition to Accupro, alcohol or if you are dehydrated or on dialysis. If you feel light headed or faint, lie down until this feeling passes.
- Other very rare but serious side effects include yellow eyes and skin (jaundice), severe abdominal and back pain (pancreatisis), weakness of arms, legs or problems speaking (possible stroke).
Other side-effects which may occur are:
- Dry cough which persists.
- Nausea, vomiting, diarrhoea, constipation, indigestion, flatulence, upset stomach or stomach pain.
- Headache, dizziness, spinning sensation, flushing, being unable to sleep, feeling tired, drowsy or run down or generally feeling weak.
- Colds, bronchitis or viral infections
- Pain in the back, chest, muscles or joints (gout).
- Skin rash, itching or increased sensitivity to light. Serious allergic reaction with a skin reaction
- Kidney disease (your doctor may carry out tests at times during your treatment if he thinks you may be at risk from kidney disease).
Side effects that occur more rarely include: increased perspiration, dry mouth/throat, hair loss, impotence, urinary infection, tingling in hands or feet, blisters, depression, confusion, nervousness, ringing in the ears, blurred vision, taste disturbances.
If these or any other effects are troublesome or do not go away you should see your doctor or pharmacist.
If you experience any dizzy spells you should avoid driving or operating heavy machinery.
Accupro may cause certain changes in your blood and your doctor may do blood tests to monitor this. If you notice bruising, feeling very tired or if you are diabetic and notice sugar levels rising let your doctor know so blood tests can be arranged if necessary.
6. How to store Accupro
- Keep the tablets in a dry place at normal room temperature (below 25°C) in the packaging they come in.
- Remember, as with all medicines, to keep Accupro away from children.
- Do not use the tablets after the expiry date on the package. For example \"EXP 11-05\" means you should not take your tablets after Nov 2005. Return any out-of-date tablets to your pharmacist.
- If your doctor decides to end your treatment, return the leftover tablets to your pharmacist. Only keep them if your doctor tells you to.
Please take Accupro Tablet 40mg as prescribed by your doctor or medical professional. Direction details will be available on your medication container.
Please contact your doctor or medical practitioner to understand more about the side effects of taking Accupro Tablet 40mg.