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There are two active ingredients in ‘Cozaar’-Comp. These are losartan potassium and hydrochlorothiazide. ‘Cozaar’-Comp 50/12.5 is available as yellow, oval, film-coated tablets marked ‘717’ on one side, containing 45.8 mg of losartan, present as 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide.
Hydroxypropylcellulose E463; hypromellose E464; lactose monohydrate; magnesium stearate E572; microcrystalline cellulose E460; pregelatinised maize starch; titanium dioxide E171; quinoline yellow aluminium lake E104; carnauba wax.
Although this medicine contains a very small amount of potassium, it cannot replace potassium supplements. If your doctor has prescribed potassium supplements, continue to follow the advice given.
‘Cozaar’-Comp contains two active ingredients. These are losartan potassium and hydrochlorothiazide. Losartan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin II is a chemical occurring in the body, which tightens your blood vessels making it harder for the blood to pass through them and causing your blood pressure to increase. ‘Cozaar’-Comp blocks this effect of angiotensin II, causing the blood vessels to relax. Hydrochlorothiazide works by making your kidneys pass more water and salt. Together, losartan and hydrochlorothiazide lower high blood pressure.
In patients with high blood pressure who have developed thickening of the heart muscle, ‘Cozaar’-Comp may help to lower the risk of stroke. There are no data to support this effect in Black patients.
Your doctor has prescribed ‘Cozaar’-Comp because you have a condition known as hypertension, or high blood pressure and you may also have thickening of the heart muscle (left ventricular hypertrophy).
Blood pressure is the term given to the pressure produced by your heart pumping blood to all parts of your body. Your blood pressure is measured by two numbers, e.g. 120/80 mm Hg. The top number measures the pressure while your heart beats and the bottom number measures the pressure in between heartbeats.
Normal blood pressure is part of good health. High blood pressure is caused when the blood vessels tighten and the measurement goes above the normal range for your age. There are usually no symptoms of high blood pressure and you will only know you have it if you have had your blood pressure measured.
Although you might feel quite well, if your high blood pressure is not treated, it can damage your heart and kidneys, and in some cases lead to stroke, heart attack, heart and/or kidney failure, or blindness.
High blood pressure can be treated and controlled with medicines such as ‘Cozaar’-Comp. Your doctor may also recommend that you make some changes to your lifestyle to help your high blood pressure, such as losing weight, keeping alcohol intake moderate or avoiding it altogether, stopping smoking, and reducing the amount of salt in your diet. Your doctor may also encourage you to take more mild exercise.
This medicine should not be given to children.
It is important to tell your doctor before taking ‘Cozaar’-Comp if you suffer from gout, diabetes, lupus erythematosus, or if you are being treated with other diuretics (water tablets). In these cases, your doctor may need to adjust the dose of your medications.
Tell your doctor if you have recently suffered from excessive vomiting and/or diarrhoea or if you have been diagnosed as having parathyroid problems.
Tell your doctor if you have a condition called ‘aortic stenosis’ or ‘outflow obstruction’. This is a condition where one of the valves in your heart doesn’t open fully and blocks the flow out of the heart.
If you have received a kidney transplant you should inform your doctor.
You should also tell your doctor if you know that you have high levels of potassium in your blood (hyperkalaemia) or you are on a low potassium diet.
Before surgery and anaesthesia (even at the dentist), tell the doctor or dentist that you are taking this medicine, as there may be a sudden fall in blood pressure associated with the anaesthesia. In addition, if you are going to have a blood test, you should let your doctor know that you are taking ‘Cozaar’-Comp. This medicine can affect the results of some diagnostic tests.
In general, ‘Cozaar’-Comp can be taken with other drugs. You should tell your doctor about all drugs that you are taking or plan to take, including those obtained without a prescription.
You should also tell your doctor if you are taking any of the following:
When some people take a medicine to lower their blood pressure, they can feel dizzy or faint, particularly if they stand up quickly. This effect can be exaggerated in some patients shortly after drinking alcohol. If this happens to you, then you should avoid drinking alcohol.
‘Cozaar’-Comp should be taken by mouth.
You must keep taking ‘Cozaar’-Comp every day and exactly as your doctor has told you. It is important that you take this medicine for as long as your doctor prescribes.
If you are aged over 75 years you should check with your doctor before taking your tablets.
The usual starting dose is 50 mg of losartan once daily. If goal blood pressure is not reached with losartan 50 mg, your doctor may prescribe a combination of losartan and low dose hydrochlorothiazide (12.5 mg). Your doctor will increase the amounts of losartan and hydrochlorothiazide step by step until the dose that is right for you has been achieved.
Try to take ‘Cozaar’-Comp daily as prescribed. However, if you miss a dose, just carry on with the next dose as normal. Do not take an extra tablet to make up.
Any medicine may have unintended or undesirable effects, so-called side effects. They are generally mild and do not normally require treatment to be interrupted. Most patients do not have side-effects from ‘Cozaar’-Comp; however, some patients may experience dizziness, cough, diarrhoea and rarely hepatitis (inflammation of the liver, symptoms of which are yellowing of the whites of the eyes and skin and flu-like symptoms).
Some patients may present with hives. Rarely, patients have reported developing an allergic reaction involving swelling of the face, lips, tongue, and/or throat which may cause difficulty in breathing or swallowing, and/or inflammation of blood vessels including inflammation of small veins, causing hard, purple blotches on the skin If you develop any of these symptoms stop taking your tablets and contact your doctor immediately.
Few patients have reported: a rapid lowering in blood pressure (symptoms of which may be lightheadedness or dizziness, particularly when standing up); rash, itching; muscle pain; migraine; liver problems (signs of which may be yellowing of the eyes and skin and flu like symptoms), or anaemia (symptoms may be tiredness or shortness of breath caused by the number of red blood cells or amount of haemoglobin in the blood being below normal) which are usually detected by blood tests.
loss of appetite; stomach upsets; nausea; vomiting; stomach cramps; constipation; jaundice seen as yellowing of the skin and/or whites of the eyes; an inflamed pancreas marked by pain in the abdomen and back; swelling of the salivary glands; vertigo (spinning sensation); pins and needles; headache; visual changes which can make objects appear yellow; anaemia marked by unusual tiredness and a loss of colour in the linings of the eyes and skin; other blood disorders which can result in fever; sore throat or prolonged bleeding after injury; increased skin sensitivity to sunlight; purplish or reddish-brown marks on the skin; fever; hives or a nettle-like rash, inflammation of blood vessels; breathing problems due to inflamed or swollen lungs; allergic reactions marked by rash, hives, or difficulties in breathing or swallowing; blistering or peeling of the skin, mouth, eyes or genitals; changes in the levels of certain chemicals in the blood and urine which are usually detected by blood and urine tests; kidney problems; muscle spasm; weakness; restlessness; blurred vision.
If you notice any of these effects, or if you have any other unusual symptoms or feelings, contact your doctor immediately.
Keep your tablets out of the reach of children.
Do not store above 30°C. Store in original package.
Do not put the tablets into another container, they might get mixed up. Do not remove the tablets from the blister pack or open the blister pack until you are ready to take the medicine.
Do not take the tablets past the expiry date, which is clearly marked on the pack.
REMEMBER: This medicine is for you. Do not share it with anyone else. It may not suit them.
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