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Chlorambucil Tablets 2mg is a private prescription item that is indicated for the treatment of Hodgkin’s disease, non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, and Waldenstrom's macroglobulinaemia. To purchase this item you must have a private prescription from your doctor or medical profession. If you require any help or assistance with purchasing Chlorambucil Tablets, then please contact our pharmacy team.
Caution before taking Chlorambucil Tablets 2mg:
Continued treatment with chlorambucil should be assessed if a rash develops since there have been reports of Stevens-Johnson Syndrome in patients receiving chlorambucil.
Chlorambucil is an active cytotoxic agent and should only be administrated under the direction of a specialist oncology service having the facilities for regular monitoring of clinical biochemical and haematological effects during and after the treatment.
Chlorambucil may cause suppression of ovarian function and amenorrhoea has been reported following chlorambucil therapy.
Azoospermia have been observed as a result of therapy with chlorambucil although it is estimated that a total dose of at least 400 mg is necessary.
Varying degrees of recovery of spermatogenesis have been reported in patients with lymphoma following treatment with Chlorambucil in total doses of 400-2600 mg.
As with other cytotoxic agents Chlorambucil is potentially teratogenic.
As with all cytotoxic therapy chemotherapy, adequate contraceptive precautions should be advised when either partner is receiving Chlorambucil.
The use of Chlorambucil should be avoided whenever possible during pregnancy, particularly during the first trimester. In any individual case, the potential hazard to the foetus must be balanced against the expected benefit to the mother.
Mothers receiving Chlorambucil should not breast feed.
Neoplasms, benign, malignant, and unspecified (including cysts and polyps): Common: Acute secondary haematologic malignancies (especially leukaemia and myelodysplastic syndrome), particularly after long term treatment.
Blood and lymphatic system disorders Very common: Leucopenia, neutropenia, thrombocytopenia, pancytopenia or bone marrow suppression. Common: Anaemia. Very rare: Irreversible bone marrow failure. Although bone marrow suppression frequently occurs, it is usually reversible if Chlorambucil is withdrawn early enough.
Immune system disorders Uncommon: Rash. Rare: Allergic reactions such as urticaria and angioneurotic oedema following initial or subsequent dosing. Stevens-Johnson syndrome and toxic epidermal necrolysis. On rare occasions skin rash has been reported to progress to serious conditions including Stevens-Johnson Syndrome and toxic epidermal necrolysis.
Nervous system disorders Common: Seizures in children with nephrotic syndrome. Rare: Seizures, focal and/or generalised in children and adults receiving therapeutic daily doses or high pulse dosing regimens of chlorambucil. Very rare: Movement disorders including tremor, twitching and myoclonia in the absence of convulsions. Peripheral neuropathy.
Respiratory, thoracic and mediastinal disorders Very rare: Interstitial pulmonary fibrosis, interstitial pneumonia. Severe interstitial pulmonary fibrosis has occasionally been reported in patients with chronic lymphocytic leukaemia on long-term Chlorambucil therapy. However, this may be reversible on withdrawal of Chlorambucil.
Gastrointestinal disorders Common: Gastro-intestinal disturbances such as nausea and vomiting, diarrhoea and oral ulceration.
Hepatobiliary disorders Rare: Hepatoxicity, jaundice.
Skin and subcutaneous tissue disorders Uncommon: Rash. Rare: Allergic reactions such as urticaria and angioneurotic oedema following initial or subsequent dosing. Stevens-Johnson syndrome and toxic epidermal necrolysis. On rare occasions skin rash has been reported to progress to serious conditions including Stevens-Johnson syndrome and toxic epidermal necrolysis.
Renal and urinary disorders Very rare: Sterile cystitis.
General disorders and administration site conditions Rare: Drug fever.
Chlorambucil Tablets 2mg contain:
Each tablet contains 2 mg of the active ingredient chlorambucil. Each tablet also contains 67.65 mg of lactose Tablet Core: Microcrystalline cellulose (E460) Anhydrous lactose Colloidal anhydrous silica Stearic acid (E570) Tablet Film Coating: Hypromellose Titanium dioxide (E171) Synthetic yellow iron oxide (E172) Synthetic red iron oxide (E172) Macrogol
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