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Bonefos Capsule 400mg contains the active ingredient sodium clodronate, which is a type of medicine called bisphosphonate and works by reducing the bone turnover in the body. As bone is not a static structure and can be continually reshaped, reformed and rebuilt it is vulnerable to excessive breakdown. This is particularly prominent in breast cancer that has spread into the bones and bone marrow cancer, which can lead to areas of bone weakness, pain and fractures. The ibandronic acid works by binding tightly to the bone tissue and prevents calcium from being removed and escaping into the blood in order to prevent the bone from breaking down further.
This means Bonefos can be used for managing bone complications (like bone pain, bone damage, or high blood calcium levels) in people with bone marrow cancer (multiple myeloma) or breast cancer that has spread to the bone. Also, as the ibandronic acid prevents calcium from being removed from the bone, it can relieve common symptoms of high blood calcium levels like nausea, tiredness and confusion.
Directions for taking Bonefos Capsule 400mg:
Caution before taking Bonefos Capsule 400mg:
Use with caution in:
Not to be used in:
Possible side effects from taking Bonefos Capsule 400mg:
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Common (affecting between 1 in 10 and 1 in 100 people):
Nausea and vomiting, diarrhoea, low level of calcium in the blood (hypocalcaemia)
Rare (affecting between 1 in 1000 and 1 in 10,000 people):
Low level of calcium in the blood that causes noticeable symptoms such as pins and needles or muscle spasms/twitches/cramps (tell your doctor if you experience symptoms like these), allergic skin reactions (rash, hives, itching), breathing difficulties due to a narrowing of the airways (bronchospasm), unusual fractures of the thigh bone
Kidney problems like decreased kidney function, kidney damage, or kidney failure, Osteonecrosis of the jaw
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