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Bonefos Capsule 400mg

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Delivery information Product #0011865

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Bonefos Capsule 400mg can be used for the management of further complications caused by cancer that has spread to the bones.

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Bonefos Capsule 400mg contains the active ingredient sodium clodronate, which is a type of medicine called bisphosphonate and works by reducing the bone turnover in the body. As bone is not a static structure and can be continually reshaped, reformed and rebuilt it is vulnerable to excessive breakdown. This is particularly prominent in breast cancer that has spread into the bones and bone marrow cancer, which can lead to areas of bone weakness, pain and fractures. The ibandronic acid works by binding tightly to the bone tissue and prevents calcium from being removed and escaping into the blood in order to prevent the bone from breaking down further.

This means Bonefos can be used for managing bone complications (like bone pain, bone damage, or high blood calcium levels) in people with bone marrow cancer (multiple myeloma) or breast cancer that has spread to the bone. Also, as the ibandronic acid prevents calcium from being removed from the bone, it can relieve common symptoms of high blood calcium levels like nausea, tiredness and confusion.

Directions for taking Bonefos Capsule 400mg:

  • Bonefos tablets and capsules are taken either once or twice a day. The dose prescribed depends on your symptoms. Follow the instructions given by your doctor. These will be printed on the dispensing label that your pharmacist has put on the packet of medicine.
  • Bonefos capsules should be swallowed whole. Bonefos tablets can be broken in half, but must not be crushed or dissolved in water before taking.
  • Bonefos tablets and capsules should be swallowed with a glass of plain water on an empty stomach. This is because food, some drinks (particularly milk and dairy products) and certain medicines can interfere with the absorption of the medicine from the gut and hence make it less effective.
  • If you are taking Bonefos once a day, your dose should be taken in the morning before the first food, drink or medicine of the day. You should not eat or drink anything other than plain water, or take any other medicines by mouth, for at least one hour after taking Bonefos.
  • If you are taking Bonefos twice a day, your first dose should be taken in the morning before the first food, drink or medicine of the day. You should then not eat or drink anything other than plain water, or take any other medicines by mouth, for at least one hour. Your second dose should be taken between meals, at least two hours after eating, drinking anything other than plain water, or taking other medicines by mouth. Again, do not eat or drink anything other than plain water, or take any other medicines by mouth, for at least one hour after taking Bonefos.

Caution before taking Bonefos Capsule 400mg:

  • It is important that you drink plenty of fluid while you are having treatment with this medicine. Ask your doctor for advice on how much you should be drinking.
  • You may need to have regular blood tests during treatment with this medicine, so that your doctor can monitor your kidney function, liver function, white blood cells and the amount of calcium in your blood.
  • The class of medicines that sodium clodronate belongs to (bisphosphonates) has been associated with a rare condition called osteonecrosis of the jaw. The majority of cases of this condition have been in cancer patients treated with bisphosphonates by injection into a vein, and many of these people were also having treatment with chemotherapy or corticosteroids. However, the condition has also been seen in people taking bisphosphonates by mouth. The risk may also be increased by poor oral hygiene, dental problems such as gum disease or poorly fitting dentures, teeth extractions, oral surgery and smoking. For this reason, you should have a dental examination and, if necessary, appropriate preventive dentistry, before you start treatment with this medicine. Discuss this with your doctor. It is important to look after your mouth and teeth as much as possible while you are taking this medicine. You should have regular check-ups with your dentist and get advice straight away if you have any problems with your mouth or teeth. When you see a dentist during treatment, make sure they know you are taking this medicine. Invasive dental procedures such as tooth extraction or surgery should be avoided if possible.
  • Some people being treated with bisphosphonates (mainly people having long-term treatment for osteoporosis) have experienced an unusual fracture of their thigh bone. For this reason it is important to let your doctor know if you get any pain in your thighs, hips or groin while you are having treatment with this medicine. These symptoms could be an early indication of a possible fracture.

Use with caution in:

  • Decreased kidney function
  • People with active disorders of the upper part of the digestive system, such as difficulty swallowing, disorders affecting the foodpipe (eg reflux disease), peptic ulcers, inflammation of the lining of the stomach (gastritis), or inflammation of the small intestine (duodenitis)

Not to be used in:

  • People being treated with other bisphosphonate medicines
  • Severe kidney failure
  • Pregnancy
  • Breastfeeding
  • This medicine has not been studied in children. It is not recommended for children

Possible side effects from taking Bonefos Capsule 400mg:

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Common (affecting between 1 in 10 and 1 in 100 people):

Nausea and vomiting, diarrhoea, low level of calcium in the blood (hypocalcaemia)

Rare (affecting between 1 in 1000 and 1 in 10,000 people):

Low level of calcium in the blood that causes noticeable symptoms such as pins and needles or muscle spasms/twitches/cramps (tell your doctor if you experience symptoms like these), allergic skin reactions (rash, hives, itching), breathing difficulties due to a narrowing of the airways (bronchospasm), unusual fractures of the thigh bone

Unknown frequency:

Kidney problems like decreased kidney function, kidney damage, or kidney failure, Osteonecrosis of the jaw

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