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Interactions and overdose

Medicine interactions

Before you start taking acetazolamide, tell your doctor about all the other medications you are presently taking, whether they are prescription, non-prescription, or herbal. Taking acetazolamide at the same time as certain other drugs may increase negative side effects and limit the effectiveness of acetazolamide. Remember that you should not start, stop, or change the dosage of any medication before discussing it with your doctor, pharmacist, or healthcare expert first.

Acetazolamide should not be used with either:

  • Cisapride
  • Methenamine

These medications along with acetazolamide can cause a very serious interaction. Tell your doctor before taking acetazolamide if you are taking any of the above medications.

Other medications that you should inform your doctor about before taking acetazolamide are:

  • Anticonvulsants: phenytoin, primidone, phenobarbital, topiramate, zonisamide
  • Carbonic anhydrase inhibitors: brinzolamide, dorzolamide
  • Cyclosporine
  • Digoxin
  • Drugs that cause loss of potassium: diuretics such as furosemide, corticosteroids such as prednisone, amphotericin B
  • Lithium
  • Memantine
  • Procainamide
  • Quinidine
  • Salicylates: aspirin, bismuth subsalicylate
  • Sodium bicarbonate
  • Tricyclic antidepressants: amitriptyline

Check any and all prescription and non-prescription labels carefully to make sure they do not contain medications similar to aspirin like anti-diarrhoea, pain relievers, and fever reduces. These may cause serious side effects when taken along with acetazolamide.

Acetazolamide may also interfere with certain laboratory and medical tests. Be sure to inform your doctor or laboratory personnel before any procedure if you are using this drug.


If you suspect an overdose of acetazolamide contact a poison control centre or emergency room immediately. Remember the following:

  • Do not change brands or dosage amounts unless you consult your doctor or pharmacist first.
  • Your prescription medications are to meet your individual health problems. Do not share medications with others.
  • Try taking your medication at the same time each day to help you not forget. If you do forget a dose, take it as soon as you remember. If you’re already near to your next dose, skip the missed one and continue with your usual schedule. Doubling your dosage to try catching up may cause an overdose.
  • Medications should be stored at room temperature between 68 and 77 degrees F, or 20 to 25 degrees C.
  • Keep medications away from moisture and sunlight.
  • Avoid storing medications in the bathroom. Instead, keep them in a designated medicine cabinet or drawer that is out of sight and out of the reach of children and pets.
  • Do not flush expired or unused medications down the toilet or pour them down the drain. All unused medications should be properly discarded if they are no longer in need. Consult your pharmacist or local waste disposal company if you are unsure of how to safely discard your old medications.