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Xenical (Orlistat) 120mg Capsules - Xenical is a medicine used to treat obesity. It works in your digestive system to block about one-third of the fat in the food you eat from being digested. Xenical attaches to the enzymes in your digestive system (lipases) and blocks them from breaking down some of the fat you have eaten during your meal. The undigested fat cannot be absorbed and is eliminated by your body. Xenical is indicated in the treatment of obesity in conjunction with a low calorie intake diet.
Is Xenical for me?
XENICAL may be right for you if you have a Body Mass Index of 30 or greater, or have a BMI of 27 or greater and have other risk factors, such as high blood pressure, high cholesterol, heart disease or diabetes.
How does XENICAL work?
If you eat an excessive amount of fat or calories, the excess is stored as fat by the body, resulting in weight gain. When you eat fat, your body breaks it down into its simplest components so that it can be digested.
Unlike other weight-loss drugs you may have heard about that act in the brain or central nervous system to suppress appetite or to speed up metabolism, XENICAL works in your digestive system to block about one-third of the fat in the food you eat from being digested.
Enzymes in your digestive system, called lipases, help digest (or break down) fat. When taken with meals, XENICAL attaches to the lipases and blocks them from breaking down some of the fat you have eaten.
The undigested fat cannot be absorbed and is eliminated in your bowel movements. By working this way, XENICAL helps block about one-third of the fat in the foods you eat from being absorbed by your body.
How is it different to other weight-loss medications?
Unlike other commonly prescribed weight-loss medications, XENICAL is not an appetite suppressant and does not have a direct effect on the brain. Instead, it works in your digestive system to block about one third of the fat in the food you eat from being digested.
If I take XENICAL, can I eat whatever I want?
The XENICAL dietary guidelines do not place any particular food out of bounds. But you may not be able to eat a lot of a particular food if it is high in calories or, especially, if it is high in fat.
How soon after starting XENICAL should I expect to notice weight loss?
Typically, people begin losing weight within 2 weeks of starting XENICAL, and may continue to lose weight for 6 to 12 months, at which point weight loss usually begins to level off -- even if you’re still taking XENICAL. This doesn’t mean that XENICAL is not working. People who continue to take XENICAL are better able to maintain their weight loss. Keep your doctor informed about your progress so that he or she can make sure your diet and your level of physical activity remain appropriate to your weight-loss goals. Once you reach your initial goal, you may want to set a new goal and have your doctor re-evaluate your calorie and activity levels.
How much weight should I expect to lose?
The amount of weight you lose depends on how well you stick to a reduced-calorie diet with no more than 30% of calories from fat and an appropriate physical activity level, as well as on your compliance with the prescribed medication regimen.
Xenical (Orlistat) 120mg Capsules - Always take Xenical exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. The usual dose of Xenical is one 120 mg capsule taken with each of the three main meals per day. It can be taken immediately before, during a meal or up to one hour after a meal. The capsule should be swallowed with water.
Xenical should be taken with a well-balanced, calorie controlled diet that is rich in fruit and vegetables and contains an average of 30 % of the calories from fat. Your daily intake of fat, carbohydrate and protein should be distributed over three meals. This means you will usually take one capsule at breakfast time, one capsule at lunch time and one capsule at dinner time. To gain optimal benefit, avoid the intake of food containing fat between meals, such as biscuits, chocolate and savoury snacks.
Xenical only works in the presence of dietary fat. Therefore, if you miss a main meal or if you have a meal containing no fat, Xenical need not be taken.
Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed. Otherwise, your doctor may think that it was not effective or well tolerated and may change your treatment unnecessarily.
Your doctor will discontinue the treatment with Xenical after 12 weeks if you have not lost at least 5 % of your body weight as measured at the start of treatment with Xenical. Xenical has been studied in long-term clinical studies of up to 4 years duration.
If you take more Xenical than you should:
If you take more capsules than you have been told to take, or if someone else accidentally takes your medicine, contact a doctor, pharmacist or hospital as you may need medical attention.
If you forget to take Xenical:
If you forget to take your medicine at any time, take it as soon as you remember provided this is within one hour of your last meal, then continue to take it at the usual times. Do not take a double dose.
If you have missed several doses, please inform your doctor and follow the advice given to you.
Do not change the prescribed dose yourself unless your doctor tells you to.
If you have further questions on the use of this medicine, ask your doctor or pharmacist
Take special care with Xenical:
Weight loss may also affect the dose of medicines taken for other conditions (e.g. high cholesterol or diabetes). Be sure to discuss these and other medicines you may be taking with your doctor. Losing weight may mean you need adjustments to the dose of these medicines.
To gain the maximum benefit from Xenical you should follow the nutrition program recommended to you by your doctor. As with any weight-control program, over-consumption of fat and calories may reduce any weight loss effect.
This medicine can cause harmless changes in your bowel habits, such as fatty or oily stools, due to the elimination of undigested fat in your faeces. The possibility of this happening may increase if Xenical is taken with a diet high in fat. In addition your daily intake of fat should be distributed evenly over three main meals because if Xenical is taken with a meal very high in fat, the possibility of gastrointestinal effects may increase.
The use of an additional contraceptive method is recommended to prevent possible failure of oral contraception that could occur in case of severe diarrhoea.
Use in Children:
Xenical is not intended to be used in children.
Taking other medicines:
Please inform your doctor or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed.
This is important as using more than one medicine at the same time can strengthen or weaken the effects of the medicines.
Xenical may modify the activity of:
Anticoagulant drugs (e.g. warfarin). Your doctor may need to monitor your blood coagulation.
Ciclosporin. Co-administration with ciclosporin is not recommended. Your doctor may need to monitor your ciclosporin blood levels more frequently than usual.
Xenical reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. You should therefore follow your doctor’s advice in taking a well balanced diet rich in fruit and vegetables and in taking. Your doctor may suggest you take a multivitamin supplement.
Pregnancy and breast-feeding:
Taking Xenical during pregnancy is not recommended.
You must not breast-feed your infant during treatment with Xenical as it is not known whether Xenical passes into human milk.
Driving and using machines:
Xenical has no known effect on your ability to drive a car or operate machinery.
Xenical (Orlistat) 120mg Capsules - Like all medicines, Xenical can cause side effects, although not everybody gets them. Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Xenical.
The majority of unwanted effects related to the use of Xenical result from its local action in your digestive system. These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.
Very common side effects (affects more than 1 user in 10)
Headache, abdominal pain/discomfort, urgent or increased need to open the bowels, flatulence (wind) with discharge, oily discharge, oily or fatty stools, liquid stools, low blood sugar levels (experienced by some people with type 2 diabetes).
Common side effects (affects 1 to 10 users in 100)
Rectal pain/discomfort, soft stools, incontinence (stools), bloating (experienced by some people with type 2 diabetes), tooth/gum disorder, irregularity of menstrual cycle, tiredness.
The following side effects have also been reported but their frequency cannot be estimated from the available data:
Allergic reactions. The main symptoms are itching, rash, wheals (slightly elevated, itchy skin patches that are paler or redder than surrounding skin), severe difficulty in breathing, nausea, vomiting and feeling unwell. Bleeding from the back passage (rectum). Increases in the levels of some liver enzymes may be found in blood tests, diverticulitis, gallstones, hepatitis (inflammation of the liver), pancreatitis (inflammation of the pancreas), skin blistering (including blisters that burst), effects on clotting with anti-coagulants.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
I have had success with these twice now - the first time was a few years ago when they first came out when I managed to lose a steady 2 and a half stone over 18 months. I then managed to maintain my optimum weight as the tablets had motivated me to adopt a low fat eating regime but without having the count the calories and be obsessive about it. The main rule of thumb is, dont let anything pass your lips that has more than 5g of fat per 100g and you cant go far wrong. The only reason I put weight on again (about 2 or 3 years later) was because of some medication I was taking for another condition. Once that was sorted and I came off the medication, I was able to start a course of Xenical again and again managed to lose quite a bit of weight again but becuase of the shortages last year I wasnt able to get them for quite a few months and by the time they were back in stock, my prescription had expired and I didnt weigh enough to go back on them. I would definitely recommend them but you cant expect them to give you an easy ride - ie you do have to eat low fat (or suffer the consequences) - dont expect to be able to eat crisps, burgers etc and just take a tablet and lose weight - it wont work and youll end up up having lots of accidents!!