Specially formulated by Bioconcepts nutritionists, Methylsulfonylmethane (MSM) 650mg is a naturally occurring sulphur compound that plays a role in promoting growth &maintenance of connective tissues and joint health.
MSM supplements support joint health
Promotes growth & maintenance of connective tissues
MSM supplements contains sulphur – a vital component necessary for formation of bones & collagen
Bioconcepts MSM is typically accompanied by Bioconcepts Glucosamine 1000mg as studies have shown results to joint health are far greater when used in combination.
What is MSM?
MSM is a naturally occurring sulphur-based compound that is utilised by the body as an important structural component of cartilage and plays a fundamental role in helping to maintain joint health.
MSM is one of the major building blocks of Glycosaminoglycans (structural components in cartilage) and plays a significant part in the preservation of joint health. Sulphur is also required for the formation of many proteins within the body, including muscles, hair and skin and is a vital component of bones, teeth and collagen.
Why take MSM?
MSM has been used in connection with Osteoarthritis.
About osteoarthritis
Osteoarthritis (OA) is a chronic disease of the joints, especially the weight-bearing joints that develops when the linings of joints degenerate, leading to lipping and spurring of bone, pain, and decreased mobility and function.
OA is a universal consequence of ageing among animals with a bony skeleton. Many factors contribute to the development of OA; the disease is primarily associated with ageing and injury and was once called 'wear-and-tear' arthritis.
What are the symptoms?
The onset of OA is gradual and most often affects the hips, knees, fingers, and spine, although other joints also may be involved. Pain is the main symptom, which usually worsens with exercise and is relieved by rest. Morning stiffness is also common and diminishes with movement. As OA progresses, joint motion is lost, and tenderness and grating sensations may develop. OA of the spine may lead to shooting pains down the arms or legs.
As MSM is an important structural component of cartilage, and plays a vital role in helping to maintain joint health, it remains that MSM is a joint element you cannot afford to live without.
How does MSM work? The science behind the secret…
MSM is a supplemental version of sulphur. Sulphur is in our bones, joints, and skin & muscle tissues and is involved in producing collagen (the primary component of connective tissue). MSM contains high amounts of sulphur. Regular supplementation is important as, as we age, the body's levels of MSM diminish.
Sulphur helps maintain joint health by forming the connective tissue important for joint cushioning, including tendons, ligaments and cartilageand may help reduce pain in the body by slowing down the nerve impulses that send pain signals to your brain.
Recent Studies
MSM helps reduce arthritis joint pain
A clinical trial titled 'Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial' by Kim et al published in the March 2006 issue of "Osteoarthritis and Cartilage" studied 50 men and women ages 40-76 with knee osteoarthritis pain. When compared to a placebo group, those who took 3 g of MSM daily for 12 weeks reported a substantial decrease in pain and function impairment. No serious adverse effects were reported. Researchers determined, however, that further studies are required to assess long-term benefits of MSM.
MSM combined with Glucosamine enhances results
A study conducted by Usha et al titled 'Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis' was published in the 'Clinical Drug Investigation' Volume 24, Number 6, 2004. They discovered that combining MSM with Glucosamine enhanced the pain-relieving benefits than MSM alone.
Objective:
Glucosamine, classified as a slow-acting drug in osteoarthritis (SADOA), is an efficacious chondroprotective agent. Methylsulfonylmethane (MSM), the isoxidised form of dimethyl-sulfoxide (DSMO), is an effective natural analgesic and anti-inflammatory agent. The aim of this study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.
Patients and design:
A total of 118 patients of either sex with mild to moderate osteoarthritis were included in the study and randomised to receive either Glu 500mg, MSM 500mg, Glu and MSM or placebo capsules three times daily for 12 weeks. Patients were evaluated at 0 (before drug administration), 2, 4, 8 and 12 weeks post-treatment for efficacy and safety. The efficacy parameters studied were the pain index, the swelling index, visual analogue scale pain intensity, 15m walking time, the Lequesne index, and consumption of rescue medicine.
Conclusion:
Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. All the treatments were well tolerated.
The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis.
Is MSM right for me?
MSM contains sulphur which has been shown to help promote the growth and repair of connective tissues. It has also been shown to slow down the nerve impulses that send pain signals to your brain helping to decrease pain associated with arthritis. For added benefit, take MSM with BioconceptsGlucosamine 1000mg or Bioconcepts Glucosamine & Chondroitin for improved joint health & mobility and a decrease in joint pain and inflammation.
In The Press
Methyl Sulphonyl Methane – Arthritis Health Article: Daily Mail:
MSM is a natural constituent of most foodstuffs, both animal and vegetable, which provides an organic source of sulphur and is a natural precursor of the essential amino acids methionine and cysteine. MSM is becoming increasingly popular as a supplement designed to reduce allergic reactions to pollen and foods, and as an alleviator of the pain and inflammation associated with arthritis, sporting injuries and other, similar conditions.
MSM is chemically quite similar to another health supplement, DMSO (Dimethyl sulfoxide), and is often referred to as DMSO2. There is some degree of uncertainty surrounding the purported health benefits of MSM; a few studies have looked at the effectiveness of MSM for athletic injuries and arthritis yet more studies are undoubtedly needed to prove the benefits conclusively.
MSM is marketed both as a single-ingredient product and combined with various other ingredients. It is available for oral use in capsules and tablets, and for application to the skin in a lotion, cream or gel. According to Robert M Herschler, a research biochemist and patent-holder for MSM, an intake of 0.5 to 1mg per kilogram of body weight per day is 'desirable'.
Glucosamine, Chondroitin, MSM plus Vitamin C - joint mobilityHealth Article: Daily Mail:
Combining MSM with Glucosamine & Chondroitin may enhance the effects even further.
Glucosamine is a key element in the framework that supports collagen-based tissues within the body structure, believed to help maintain fluidity of movement and alleviate the problems of stiffness and pain that are normally associated with osteoarthritis and joint wear and tear due to old age or injury.
Chondroitin is a component of cartilage that helps it to attract and retain water. It also helps to support the elasticity of cartilage and joints, and to prevent joint stiffness. Chondroitin is also found in the walls of blood vessels, and may help in maintaining their health.
MSM, sometimes known as DMSO2, is a natural constituent of most foods, which provides an organic source of sulphur and is a natural precursor of the essential amino acids methionine and cysteine. It is increasingly becoming popular as a way of relieving the pain and inflammation associated with arthritis, sporting injuries and other similar conditions.
The combination of these three ingredients is aimed towards anyone who may need to prevent or treat joint inflammation, stiffness, injury and improve mobility.
Always follow the instructions carefully Please tell your doctor or pharmacist about all the medicines you are taking, have recently taken or plan to take, including prescription and non-prescription medicines, dietary supplements and herbal remedies. Your doctor will decide if you can take this supplement with your If you take this supplement at the same time as some other medicines, the treatment may be affected and so caution is needed. If you are uncertain about how to take your medicine ask your doctor or pharmacist for advice Do not take if you are allergic (hypersensitive) to any of the ingredients. You should carefully read all product packaging and labels prior to use
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